College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. Electronic address: Gary-Raskob@ouhsc.edu. Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy. Department of Haematological Medicine, Guy's and St Thomas' Hospitals, King's College London, London, UK. Department of Vascular Medicine, Academic Medical Center, Amsterdam, Netherlands. Clinical Development, Daiichi Sankyo Pharma Development, Edison, NJ, USA. ITREAS Clinical Research, Amsterdam, Netherlands. Division of Respiratory and Intensive Care Medicine, Hopital Europeen George Pompidou, INSERM UMR_S 970, CIC 1418, Université Paris Descartes, Paris, France. Vascular Medicine and Hemostasis, University of Leuven, Leuven, Belgium. Ottawa Hospital Research Institute, Department of Medicine, University of Ottawa, Ottawa, ON, Canada. Medical Affairs, Daiichi Sankyo Inc, Parsippany, NJ, USA. Thrombosis & Atherosclerosis Research Institute and McMaster University, Hamilton, Ontario, Canada.